Local Exome Sequences Facilitate Imputation of Less Common Variants and Increase Power of Genome Wide Association Studies

The analysis of less common variants in genome-wide association studies promises to elucidate complex trait genetics but is hampered by low power to reliably detect association. We show that addition of population-specific exome sequence data to global reference data allows more accurate imputation,...

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Hauptverfasser: Joshi, Peter K., Prendergast, James, Fraser, Ross M., Huffman, Jennifer E., Vitart, Veronique, Hayward, Caroline, McQuillan, Ruth, Glodzik, Dominik, Polašek, Ozren, Hastie, Nicholas D., Rudan, Igor, Campbell, Harry, Wright, Alan F., Haley, Chris S., Wilson, James F., Navarro, Pau
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712964/
https://ncbi.nlm.nih.gov/pubmed/23874685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068604
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