Identification of a broad-spectrum inhibitor of virus RNA synthesis: validation of a prototype virus-based approach

There are no approved therapeutics for the most deadly nonsegmented negative-strand (NNS) RNA viruses, including Ebola (EBOV). To identify new chemical scaffolds for development of broad-spectrum antivirals, we undertook a prototype-based lead identification screen. Using the prototype NNS virus, ve...

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Detalhes bibliográficos
Main Authors: Filone, Claire Marie, Hodges, Erin N., Honeyman, Brian, Bushkin, G. Guy, Boyd, Karla, Platt, Andrew, Ni, Feng, Strom, Kyle, Hensley, Lisa, Snyder, John K., Connor, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712830/
https://ncbi.nlm.nih.gov/pubmed/23521799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.02.011
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