Novel Nitrogen-Enriched Oridonin Analogs with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility

Oridonin (1), a complex ent-kaurane diterpenoid isolated from the traditional Chinese herb Isodon rubescens, has demonstrated great potential in the treatment of various human cancers due to its unique and safe anticancer pharmacological profile. Nevertheless, the clinical development of oridonin fo...

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Hauptverfasser: Ding, Chunyong, Zhang, Yusong, Chen, Haijun, Yang, Zhengduo, Wild, Christopher, Chu, Lili, Liu, Huiling, Shen, Qiang, Zhou, Jia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712786/
https://ncbi.nlm.nih.gov/pubmed/23746196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400367n
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