Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a c...

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Main Authors: McCary, Christine, Tancowny, Brian P., Catalli, Adriana, Grammer, Leslie C., Harris, Kathleen E., Schleimer, Robert P., Kulka, Marianna
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712287/
https://ncbi.nlm.nih.gov/pubmed/20117843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2009.12.006
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