Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a c...

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Библиографические подробности
Главные авторы: McCary, Christine, Tancowny, Brian P., Catalli, Adriana, Grammer, Leslie C., Harris, Kathleen E., Schleimer, Robert P., Kulka, Marianna
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712287/
https://ncbi.nlm.nih.gov/pubmed/20117843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2009.12.006
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