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In vivo studies of Scn5a+/− mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities

OBJECTIVES: We investigate the extent to which the electrocardiographic (ECG) properties of intact Scn5a+/− mice reproduce the corresponding clinical Brugada syndrome phenotype and use this model to investigate the role of conduction and repolarization abnormalities in the arrhythmogenic mechanism....

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Autori principali: Martin, Claire A., Zhang, Yanmin, Grace, Andrew A., Huang, Christopher L.-H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Churchill Livingstone 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712183/
https://ncbi.nlm.nih.gov/pubmed/20638671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jelectrocard.2010.05.015
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