Prevalence of Neutralizing Antibodies to Adenoviral Serotypes 5 and 35 in the Adult Populations of The Gambia, South Africa, and the United States

One of the major limitations of the use of adenoviruses as gene therapy vectors is the existence of preformed immunity in various populations. Recent studies have linked failure of adenoviral gene therapy trials to the presence of antiadenoviral neutralizing antibodies (NAb). Understanding the distr...

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Hlavní autoři: Nwanegbo, Edward, Vardas, Eftyhia, Gao, Wentao, Whittle, Hilton, Sun, Huijie, Rowe, David, Robbins, Paul D., Gambotto, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Microbial Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC371218/
https://ncbi.nlm.nih.gov/pubmed/15013987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.11.2.351-357.2004
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