Prevalence of Neutralizing Antibodies to Adenoviral Serotypes 5 and 35 in the Adult Populations of The Gambia, South Africa, and the United States

One of the major limitations of the use of adenoviruses as gene therapy vectors is the existence of preformed immunity in various populations. Recent studies have linked failure of adenoviral gene therapy trials to the presence of antiadenoviral neutralizing antibodies (NAb). Understanding the distr...

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Detalhes bibliográficos
Main Authors: Nwanegbo, Edward, Vardas, Eftyhia, Gao, Wentao, Whittle, Hilton, Sun, Huijie, Rowe, David, Robbins, Paul D., Gambotto, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Microbial Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC371218/
https://ncbi.nlm.nih.gov/pubmed/15013987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.11.2.351-357.2004
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