Role of N-acetylcysteine and GSH redox system on total and active MMP-2 in intestinal myofibroblasts of Crohn's disease patients

PURPOSE: Intestinal subepithelial myofibroblasts (ISEMFs)(1) are the predominant source of matrix metalloproteinase-2 (MMP-2) in gut, and a decrease in glutathione/oxidized glutathione (GSH/GSSG) ratio, intracellular redox state index, occurs in the ISEMFs of patients with Crohn’s disease (CD). The...

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Hauptverfasser: Romagnoli, Cecilia, Marcucci, Tommaso, Picariello, Lucia, Tonelli, Francesco, Vincenzini, Maria Teresa, Iantomasi, Teresa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712135/
https://ncbi.nlm.nih.gov/pubmed/23271497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00384-012-1632-2
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