Hyperglycemia-Induced Protein Kinase C β(2) Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling

Protein kinase C (PKC)β(2) is preferably overexpressed in the diabetic myocardium, which induces cardiomyocyte hypertrophy and contributes to diabetic cardiomyopathy, but the underlying mechanisms are incompletely understood. Caveolae are critical in signal transduction of PKC isoforms in cardiomyoc...

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Detalhes bibliográficos
Main Authors: Lei, Shaoqing, Li, Haobo, Xu, Jinjin, Liu, Yanan, Gao, Xia, Wang, Junwen, Ng, Kwok F.J., Lau, Wayne Bond, Ma, Xin-liang, Rodrigues, Brian, Irwin, Michael G., Xia, Zhengyuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712061/
https://ncbi.nlm.nih.gov/pubmed/23474486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1391
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