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EGFR-targeted Poly Inosine/Cytosine GE11 Polyplex Leads to Tumor Inhibition of EGFR Over-Expressing Tumors
Phage display has identified the dodecapeptide YHWYGYTPQNVI (GE11) as a ligand that binds to the EGFR but does not activate the receptor. Here we compare the EGFR binding affinities of GE11, EGF and their polyethyleneimine-polyethyleneglycol (PEI-PEG) conjugates. We find that although GE11 by itself...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711802/ https://ncbi.nlm.nih.gov/pubmed/22362419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iub.1002 |
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