EGFR-targeted Poly Inosine/Cytosine GE11 Polyplex Leads to Tumor Inhibition of EGFR Over-Expressing Tumors

Phage display has identified the dodecapeptide YHWYGYTPQNVI (GE11) as a ligand that binds to the EGFR but does not activate the receptor. Here we compare the EGFR binding affinities of GE11, EGF and their polyethyleneimine-polyethyleneglycol (PEI-PEG) conjugates. We find that although GE11 by itself...

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Main Authors: Abourbeh, Galith, Shir, Alexei, Mishani, Eyal, Ogris, Manfred, Rödl, Wolfgang, Wagner, Ernst, Levitzki, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711802/
https://ncbi.nlm.nih.gov/pubmed/22362419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iub.1002
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