A Novel Role of Cytosolic Protein Synthesis Inhibition in Aminoglycoside Ototoxicity

Ototoxicity is a main dose-limiting factor in the clinical application of aminoglycoside antibiotics. Despite longstanding research efforts, our understanding of the mechanisms underlying aminoglycoside ototoxicity remains limited. Here we report the discovery of a novel stress pathway that contribu...

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Main Authors: Francis, Shimon P., Katz, Joshua, Fanning, Kathryn D., Harris, Kimberly A., Nicholas, Brian D., Lacy, Michael, Pagana, James, Agris, Paul F., Shin, Jung-Bum
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711767/
https://ncbi.nlm.nih.gov/pubmed/23407963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3430-12.2013
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