The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic sites

The mechanistic underpinnings of metastatic dormancy and reactivation are poorly understood. A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-β ligands, induces dormant breast cancer cells to undergo reactivation in the lung. Mechanistic studies indicate that Coco exert...

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Bibliografiske detaljer
Main Authors: Gao, Hua, Chakraborty, Goutam, Lee-Lim, Ai Ping, Mo, Qianxing, Decker, Markus, Vonica, Alin, Shen, Ronglai, Brogi, Edi, Brivanlou, Ali H., Giancotti, Filippo G.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711709/
https://ncbi.nlm.nih.gov/pubmed/22901808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.035
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