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The multiple lives of NMD factors: balancing roles in gene and genome regulation

Nonsense-mediated mRNA decay (NMD) largely functions to ensure the quality of gene expression. However, NMD is also crucial to regulating appropriate expression levels for certain genes and for maintaining genome stability. Furthermore, just as NMD serves cells in multiple ways, so do its constituen...

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Detalhes bibliográficos
Main Authors: Isken, Olaf, Maquat, Lynne E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711694/
https://ncbi.nlm.nih.gov/pubmed/18679436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg2402
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