Deficits in Ventromedial Prefrontal Cortex Group 1 Metabotropic Glutamate Receptor Function Mediate Resistance to Extinction during Protracted Withdrawal from an Extensive History of Cocaine Self-Administration

Anomalies in prefrontal cortex (PFC) function are posited to underpin difficulties in learning to suppress drug-seeking behavior during abstinence. Because group 1 metabotropic glutamate receptors (mGluRs) regulate drug-related learning, we assayed the consequences of extended access to intravenous...

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Hauptverfasser: Ben-Shahar, Osnat, Sacramento, Arianne D., Miller, Bailey W., Webb, Sierra M., Wroten, Melissa G., Silva, Hannah E., Caruana, Amanda L., Gordon, Evan J., Ploense, Kyle L., Ditzhazy, Jennifer, Kippin, Tod E., Szumlinski, Karen K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711633/
https://ncbi.nlm.nih.gov/pubmed/23303930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3710-12.2013
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