Deficits in Ventromedial Prefrontal Cortex Group 1 Metabotropic Glutamate Receptor Function Mediate Resistance to Extinction during Protracted Withdrawal from an Extensive History of Cocaine Self-Administration

Anomalies in prefrontal cortex (PFC) function are posited to underpin difficulties in learning to suppress drug-seeking behavior during abstinence. Because group 1 metabotropic glutamate receptors (mGluRs) regulate drug-related learning, we assayed the consequences of extended access to intravenous...

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Main Authors: Ben-Shahar, Osnat, Sacramento, Arianne D., Miller, Bailey W., Webb, Sierra M., Wroten, Melissa G., Silva, Hannah E., Caruana, Amanda L., Gordon, Evan J., Ploense, Kyle L., Ditzhazy, Jennifer, Kippin, Tod E., Szumlinski, Karen K.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711633/
https://ncbi.nlm.nih.gov/pubmed/23303930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3710-12.2013
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