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LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gα(s)
Ligand binding to certain heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) stimulates the rapid synthesis of cyclic adenosine monophosphate (cAMP) through the G protein α(s) subunit, which activates adenylyl cyclase (AC). We found that the transmembrane recepto...
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| Asıl Yazarlar: | , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711537/ https://ncbi.nlm.nih.gov/pubmed/21406690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001464 |
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