SIRT3 is a Mitochondrial Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism During Stress

The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(−/−) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and genomic in...

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Detalhes bibliográficos
Main Authors: Kim, Hyun-Seok, Patel, Krish, Muldoon-Jacobs, Kristi, Bisht, Kheem S., Aykin-Burns, Nukhet, Pennington, J. Daniel, van der Meer, Riet, Nguyen, Phuongmai, Savage, Jason, Owens, Kjerstin M., Vassilopoulos, Athanassios, Ozden, Ozkan, Park, Seong-Hoon, Singh, Keshav K., Abdulkadir, Sarki A., Spitz, Douglas R., Deng, Chu-Xia, Gius, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711519/
https://ncbi.nlm.nih.gov/pubmed/20129246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.11.023
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