SIRT3 is a Mitochondrial Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism During Stress

The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(−/−) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and genomic in...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Kim, Hyun-Seok, Patel, Krish, Muldoon-Jacobs, Kristi, Bisht, Kheem S., Aykin-Burns, Nukhet, Pennington, J. Daniel, van der Meer, Riet, Nguyen, Phuongmai, Savage, Jason, Owens, Kjerstin M., Vassilopoulos, Athanassios, Ozden, Ozkan, Park, Seong-Hoon, Singh, Keshav K., Abdulkadir, Sarki A., Spitz, Douglas R., Deng, Chu-Xia, Gius, David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711519/
https://ncbi.nlm.nih.gov/pubmed/20129246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.11.023
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky