Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors

OBJECTIVES: To investigate whether monocytes contribute to matrix deposition in systemic sclerosis (SSc) by production of tissue-inhibitor of metalloproteinase-1 (TIMP-1). METHODS: Matrix metalloproteinase-1 (MMP-1) and TIMP-1 expression and secretion were measured by qRT-PCR and ELISA in circulatin...

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Autors principals: Ciechomska, Marzena, Huigens, Christiaan A, Hügle, Thomas, Stanly, Tess, Gessner, Andreas, Griffiths, Bridget, Radstake, Timothy R D J, Hambleton, Sophie, O'Reilly, Steven, van Laar, Jacob M
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2013
Matèries:
Basic and Translational Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711494/
https://ncbi.nlm.nih.gov/pubmed/23223421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-201958
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