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Real-time detection of DNA topological changes with a fluorescently labeled cruciform
Topoisomerases are essential cellular enzymes that maintain the appropriate topological status of DNA and are the targets of several antibiotic and chemotherapeutic agents. High-throughput (HT) analysis is desirable to identify new topoisomerase inhibitors, but standard in vitro assays for DNA topol...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711437/ https://ncbi.nlm.nih.gov/pubmed/23680786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt413 |
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