The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation

The tumour-suppressor gene CDKN1A (encoding p21Waf/Cip1) is thought to be epigenetically repressed in cancer cells. FBI-1 (ZBTB7A) is a proto-oncogenic transcription factor repressing the alternative reading frame and p21WAF/CDKN1A genes of the p53 pathway. FBI-1 interacts directly with MBD3 (methyl...

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Detalhes bibliográficos
Main Authors: Choi, Won-Il, Jeon, Bu-Nam, Yoon, Jae-Hyeon, Koh, Dong-In, Kim, Myung-Hwa, Yu, Mi-Young, Lee, Kyung-Mi, Kim, Youngsoo, Kim, Kyunggon, Hur, Sujin Susanne, Lee, Choong-Eun, Kim, Kyung-Sup, Hur, Man-Wook
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711425/
https://ncbi.nlm.nih.gov/pubmed/23658227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt359
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