Anti-HIV Host Factor SAMHD1 Regulates Viral Sensitivity to Nucleoside Reverse Transcriptase Inhibitors via Modulation of Cellular Deoxyribonucleoside Triphosphate (dNTP) Levels

Newly identified anti-HIV host factor, SAMHD1, restricts replication of lentiviruses such as HIV-1, HIV-2, and simian immunodeficiency virus in macrophages by enzymatically hydrolyzing and depleting cellular dNTPs, which are the substrates of viral DNA polymerases. HIV-2 and some simian immunodefici...

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Autori principali: Amie, Sarah M., Daly, Michele B., Noble, Erin, Schinazi, Raymond F., Bambara, Robert A., Kim, Baek
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
DNA and Chromosomes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711331/
https://ncbi.nlm.nih.gov/pubmed/23744077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.472159
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