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Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird Spider Ornithoctonus hainana

In the present study, we investigated the structure and function of hainantoxin-III (HNTX-III), a 33-residue polypeptide from the venom of the spider Ornithoctonus hainana. It is a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels. HNTX-III suppressed Nav1.7 curre...

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מידע ביבליוגרפי
Main Authors: Liu, Zhonghua, Cai, Tianfu, Zhu, Qi, Deng, Meichun, Li, Jiayan, Zhou, Xi, Zhang, Fan, Li, Dan, Li, Jing, Liu, Yu, Hu, Weijun, Liang, Songping
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711305/
https://ncbi.nlm.nih.gov/pubmed/23703613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426627
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