SEC14 and Spectrin Domains 1 (Sestd1) and Dapper Antagonist of Catenin 1 (Dact1) Scaffold Proteins Cooperatively Regulate the Van Gogh-like 2 (Vangl2) Four-pass Transmembrane Protein and Planar Cell Polarity (PCP) Pathway during Embryonic Development in Mice

The planar cell polarity (PCP) pathway is a conserved non-canonical (β-catenin-independent) branch of Wnt signaling crucial to embryogenesis, during which it regulates cell polarity and polarized cell movements. Disruption of PCP components in mice, including Vangl2 and Dact1, results in defective n...

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Bibliographic Details
Main Authors: Yang, XiaoYong, Cheyette, Benjamin N. R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711279/
https://ncbi.nlm.nih.gov/pubmed/23696638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.465427
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