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Posterior Malformations in Dact1 mutant mice arise through misregulated Vangl2 at the Primitive Streak
Mice homozygous for mutations in Dact1 (Dpr/Frodo) phenocopy human malformations involving the spine, genitourinary system, and distal digestive tract. We trace this phenotype to disrupted germ layer morphogenesis at the primitive streak (PS). Remarkably, heterozygous mutation of Vangl2, a transmemb...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2733921/ https://ncbi.nlm.nih.gov/pubmed/19701191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.435 |
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