Posterior Malformations in Dact1 mutant mice arise through misregulated Vangl2 at the Primitive Streak

Mice homozygous for mutations in Dact1 (Dpr/Frodo) phenocopy human malformations involving the spine, genitourinary system, and distal digestive tract. We trace this phenotype to disrupted germ layer morphogenesis at the primitive streak (PS). Remarkably, heterozygous mutation of Vangl2, a transmemb...

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Bibliographic Details
Main Authors: Suriben, Rowena, Kivimäe, Saul, Fisher, Daniel A., Moon, Randall T., Cheyette, Benjamin N.R.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733921/
https://ncbi.nlm.nih.gov/pubmed/19701191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.435
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