A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function

The ubiquitously expressed glucocorticoid receptor (GR) is a major drug target for inflammatory disease, but issues of specificity and target tissue sensitivity remain. We now identify high potency, non-steroidal GR ligands, GSK47867A and GSK47869A, which induce a novel conformation of the GR ligand...

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Bibliographische Detailangaben
Hauptverfasser: Trebble, Peter J., Woolven, James M., Saunders, Ken A., Simpson, Karen D., Farrow, Stuart N., Matthews, Laura C., Ray, David W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711205/
https://ncbi.nlm.nih.gov/pubmed/23687373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.124784
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