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CROSSTALK BETWEEN THE AMP-ACTIVATED KINASE AND INSULIN SIGNALING PATHWAYS RESCUES MURINE BLASTOCYST CELLS FROM INSULIN RESISTANCE
Maternal insulin resistance results in poor pregnancy outcomes. In vivo and in vitro exposure of the murine blastocyst to high insulin or IGF-1 results in the down-regulation of the IGF-1 receptor (IGF-1R). This in turn leads to decreased glucose uptake, increased apoptosis as well as pregnancy reso...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711107/ https://ncbi.nlm.nih.gov/pubmed/18577554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/REP-08-0161 |
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