Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2

The retinoblastoma protein (Rb)/E2F pathway links cellular proliferation control to apoptosis and is critical for normal development and cancer prevention. Here we define a transcription-mediated pathway in which deregulation of E2F1 by ectopic E2F expression or Rb inactivation by E7 of human papill...

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Detalhes bibliográficos
Main Authors: Rogoff, Harry A., Pickering, Mary T., Frame, Fiona M., Debatis, Michelle E., Sanchez, Yolanda, Jones, Stephen, Kowalik, Timothy F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC371110/
https://ncbi.nlm.nih.gov/pubmed/15024084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2968-2977.2004
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