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Infection with retroviral vectors leads to perturbed DNA replication increasing vector integrations into fragile sites
Genome instability is a hallmark of cancer. Common fragile sites (CFSs) are specific regions in the human genome that are sensitive to replication stress and are prone to genomic instability in different cancer types. Here we molecularly cloned a new CFS, FRA11H, in 11q13. The genomic region of FRA1...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711054/ https://ncbi.nlm.nih.gov/pubmed/23852038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02189 |
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