Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer

The androgen receptor (AR) and the phosphoinositide 3-kinase (PI3K)/protein kinase B/mammalian target of rapamycin (mTOR) signaling are two of the major proliferative pathways in a number of tissues and are the main therapeutic targets in various disorders, including prostate cancer (PCa). Previous...

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Hlavní autoři: Jin, Yang, Qu, Su, Tesikova, Martina, Wang, Ling, Kristian, Alexandr, Mælandsmo, Gunhild M., Kong, Haiying, Zhang, Tianzhou, Jerónimo, Carmen, Teixeira, Manuel R., Yuca, Erkan, Tekedereli, Ibrahim, Gorgulu, Kivanc, Alpay, Neslihan, Sood, Anil K., Lopez-Berestein, Gabriel, Danielsen, Håvard E., Ozpolat, Bulent, Saatcioglu, Fahri
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710885/
https://ncbi.nlm.nih.gov/pubmed/23798432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304318110
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