Intellectual Disability Is Associated with Increased Runs of Homozygosity in Simplex Autism

Intellectual disability (ID), often attributed to autosomal-recessive mutations, occurs in 40% of autism spectrum disorders (ASDs). For this reason, we conducted a genome-wide analysis of runs of homozygosity (ROH) in simplex ASD-affected families consisting of a proband diagnosed with ASD and at le...

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Autores principales: Gamsiz, Ece D., Viscidi, Emma W., Frederick, Abbie M., Nagpal, Shailender, Sanders, Stephan J., Murtha, Michael T., Schmidt, Michael, Triche, Elizabeth W., Geschwind, Daniel H., State, Matthew W., Istrail, Sorin, Cook, Edwin H., Devlin, Bernie, Morrow, Eric M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710760/
https://ncbi.nlm.nih.gov/pubmed/23830515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.06.004
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