Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Association” Principle

To better understand different molecular mechanisms by which mutations lead to various human diseases, we classified 82,833 disease-associated mutations according to their inheritance modes (recessive versus dominant) and molecular types (in-frame [missense point mutations and in-frame indels] versu...

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Main Authors: Guo, Yu, Wei, Xiaomu, Das, Jishnu, Grimson, Andrew, Lipkin, Steven M., Clark, Andrew G., Yu, Haiyuan
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710751/
https://ncbi.nlm.nih.gov/pubmed/23791107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.05.022
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