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Sirtuin/Sir2 Phylogeny, Evolutionary Considerations and Structural Conservation
The sirtuins are a protein family named after the first identified member, S. cerevisiae Sir2p. Sirtuins are protein deacetylases whose activity is dependent on NAD(+) as a cosubstrate. They are structurally defined by two central domains that together form a highly conserved catalytic center, which...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710699/ https://ncbi.nlm.nih.gov/pubmed/19936627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-009-0169-x |
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