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Amniotic Fluid Activates the Nrf2/Keap1 Pathway to Repair an Epidermal Barrier Defect In Utero

The loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barrier formation. Therefore, the living layers of the epidermis are aberrantly exposed to late-stage amniotic fluid, which may serve as the signal to upregulate genes that functionally compensate for...

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Bibliografische gegevens
Hoofdauteurs: Huebner, Aaron J., Dai, Daisy, Morasso, Maria, Schmidt, Edward E., Schäfer, Matthias, Werner, Sabine, Roop, Dennis R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710685/
https://ncbi.nlm.nih.gov/pubmed/23237955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.11.002
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