Amino Acid 324 in the Simian Immunodeficiency Virus SIVmac V3 Loop Can Confer CD4 Independence and Modulate the Interaction with CCR5 and Alternative Coreceptors

The V3 loop of the simian immunodeficiency virus (SIV) envelope protein (Env) largely determines interactions with viral coreceptors. To define amino acids in V3 that are critical for coreceptor engagement, we functionally characterized Env variants with amino acid substitutions at position 324 in V...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Pöhlmann, Stefan, Davis, Carl, Meister, Silke, Leslie, George J., Otto, Claas, Reeves, Jacqueline D., Puffer, Bridget A., Papkalla, Armin, Krumbiegel, Mandy, Marzi, Andrea, Lorenz, Steffen, Münch, Jan, Doms, Robert W., Kirchhoff, Frank
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2004
Schlagworte:	Virus-Cell Interactions
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15016843/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.7.3223-3232.2004
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