Amino Acid 324 in the Simian Immunodeficiency Virus SIVmac V3 Loop Can Confer CD4 Independence and Modulate the Interaction with CCR5 and Alternative Coreceptors

The V3 loop of the simian immunodeficiency virus (SIV) envelope protein (Env) largely determines interactions with viral coreceptors. To define amino acids in V3 that are critical for coreceptor engagement, we functionally characterized Env variants with amino acid substitutions at position 324 in V...

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Detalhes bibliográficos
Main Authors: Pöhlmann, Stefan, Davis, Carl, Meister, Silke, Leslie, George J., Otto, Claas, Reeves, Jacqueline D., Puffer, Bridget A., Papkalla, Armin, Krumbiegel, Mandy, Marzi, Andrea, Lorenz, Steffen, Münch, Jan, Doms, Robert W., Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC371062/
https://ncbi.nlm.nih.gov/pubmed/15016843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.7.3223-3232.2004
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