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Effects of Mutations of the Initiation Nucleotides on Hepatitis C Virus RNA Replication in the Cell

Replication of nearly all RNA viruses depends on a virus-encoded RNA-dependent RNA polymerase (RdRp). Our earlier work found that purified recombinant hepatitis C virus (HCV) RdRp (NS5B) was able to initiate RNA synthesis de novo by using purine (A and G) but not pyrimidine (C and U) nucleotides (G....

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Detalhes bibliográficos
Main Authors: Cai, Zhaohui, Liang, T. Jake, Luo, Guangxiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC371060/
https://ncbi.nlm.nih.gov/pubmed/15016884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.7.3633-3643.2004
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