The C-Terminal Transmembrane Domain of Hepatitis C Virus (HCV) RNA Polymerase Is Essential for HCV Replication In Vivo

Hepatitis C virus (HCV) RNA replication is dependent on the enzymatic activities of the viral RNA-dependent RNA polymerase NS5B, which is a membrane-anchored protein. Recombinant NS5B lacking the C-terminal transmembrane domain (21 amino acids) is enzymatically active. To address the role of this do...

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Detalhes bibliográficos
Main Authors: Lee, Ki Jeong, Choi, Jinah, Ou, Jing-hsiung, Lai, Michael M. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC371049/
https://ncbi.nlm.nih.gov/pubmed/15016899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.7.3797-3802.2004
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