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A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

The unique C-terminal repeat domain (CTD) of the largest subunit (IIa) of eukaryotic RNA polymerase II consists of multiple repeats of the heptapeptide consensus sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser. The number of repeats ranges from 26 in yeast to 42 in Drosophila to 52 in mouse. The CTD is essenti...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lee, J M, Greenleaf, A L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287190/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2657724/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.10.3624
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