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The Synthetic Amphipathic Peptidomimetic LTX109 Is a Potent Fungicide That Disturbs Plasma Membrane Integrity in a Sphingolipid Dependent Manner

The peptidomimetic LTX109 (arginine-tertbutyl tryptophan-arginine-phenylethan) was previously shown to have antibacterial properties. Here, we investigated the activity of this novel antimicrobial peptidomimetic on the yeast Saccharomyces cerevisiae. We found that LTX109 was an efficient fungicide t...

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Autori principali: Bojsen, Rasmus, Torbensen, Rasmus, Larsen, Camilla Eggert, Folkesson, Anders, Regenberg, Birgitte
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709891/
https://ncbi.nlm.nih.gov/pubmed/23874964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069483
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