Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

The tight electrostatic binding of the chemokine platelet factor 4 (PF4) to polyanions induces heparin-induced thrombocytopenia, a prothrombotic adverse drug reaction caused by immunoglobulin G directed against PF4/polyanion complexes. This study demonstrates that nucleic acids, including aptamers,...

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Autors principals: Jaax, Miriam E., Krauel, Krystin, Marschall, Thomas, Brandt, Sven, Gansler, Julia, Fürll, Birgitt, Appel, Bettina, Fischer, Silvia, Block, Stephan, Helm, Christiane A., Müller, Sabine, Preissner, Klaus T., Greinacher, Andreas
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709655/
https://ncbi.nlm.nih.gov/pubmed/23673861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-478966
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