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Structural Requirements for the Procoagulant Activity of Nucleic Acids

Nucleic acids, especially extracellular RNA, are exposed following tissue- or vessel damage and have previously been shown to activate the intrinsic blood coagulation pathway in vitro and in vivo. Yet, no information on structural requirements for the procoagulant activity of nucleic acids is availa...

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Detalhes bibliográficos
Main Authors: Gansler, Julia, Jaax, Miriam, Leiting, Silke, Appel, Bettina, Greinacher, Andreas, Fischer, Silvia, Preissner, Klaus T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511531/
https://ncbi.nlm.nih.gov/pubmed/23226277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050399
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