E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

Neoplastic transformation requires the elimination of key tumor suppressors, which may result from E3 ligase-mediated proteasomal degradation. We previously demonstrated a key role for the E3 ubiquitin ligase E6AP in the regulation of promyelocytic leukemia protein (PML) stability and formation of P...

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Hlavní autoři: Wolyniec, Kamil, Shortt, Jake, de Stanchina, Elisa, Levav-Cohen, Yaara, Alsheich-Bartok, Osnat, Louria-Hayon, Igal, Corneille, Vincent, Kumar, Beena, Woods, Simone J., Opat, Stephen, Johnstone, Ricky W., Scott, Clare L., Segal, David, Pandolfi, Pier Paolo, Fox, Stephen, Strasser, Andreas, Jiang, Yong-Hui, Lowe, Scott W., Haupt, Sue, Haupt, Ygal
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709628/
https://ncbi.nlm.nih.gov/pubmed/22689861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-387647
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