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The C terminus of NS5A domain II is a key determinant of hepatitis C virus genome replication, but is not required for virion assembly and release

The NS5A protein of hepatitis C virus (HCV) plays roles in both virus genome replication and the assembly of infectious virus particles. NS5A comprises three domains, separated by low-complexity sequences. Whilst the function of domain I appears to be predominantly involved with genome replication,...

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Bibliographic Details
Main Authors: Ross-Thriepland, Douglas, Amako, Yutaka, Harris, Mark
Format: Artigo
Language:Inglês
Published: Society for General Microbiology 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709587/
https://ncbi.nlm.nih.gov/pubmed/23324467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.050633-0
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