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Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells

PURPOSE: The aim of the study is to dissect the cytotoxic mechanisms of 1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl)-4E-en-3-heptanone (compound 1) in SH-SY5Y cells and therefore to provide new insight into neuroblastoma chemotherapy. METHODS: 9 diarylheptanoids were isolated from Alpinia o...

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Hlavní autoři: Tian, Ze, An, Ning, Zhou, Bin, Xiao, Peigen, Kohane, Isaac S., Wu, Erxi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709019/
https://ncbi.nlm.nih.gov/pubmed/18836721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0832-5
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