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Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis

Nef is the viral gene product employed by the majority of primate lentiviruses to overcome restriction by tetherin (BST-2 or CD317), an interferon-inducible transmembrane protein that inhibits the detachment of enveloped viruses from infected cells. Although the mechanisms of tetherin antagonism by...

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Main Authors: Serra-Moreno, Ruth, Zimmermann, Kerstin, Stern, Lawrence J., Evans, David T.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708871/
https://ncbi.nlm.nih.gov/pubmed/23853598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003487
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