SLC26A4 Targeted to the Endolymphatic Sac Rescues Hearing and Balance in Slc26a4 Mutant Mice

Mutations of SLC26A4 are a common cause of human hearing loss associated with enlargement of the vestibular aqueduct. SLC26A4 encodes pendrin, an anion exchanger expressed in a variety of epithelial cells in the cochlea, the vestibular labyrinth and the endolymphatic sac. Slc26a4 (Δ/Δ) mice are devo...

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Autors principals: Li, Xiangming, Sanneman, Joel D., Harbidge, Donald G., Zhou, Fei, Ito, Taku, Nelson, Raoul, Picard, Nicolas, Chambrey, Régine, Eladari, Dominique, Miesner, Tracy, Griffith, Andrew J., Marcus, Daniel C., Wangemann, Philine
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708829/
https://ncbi.nlm.nih.gov/pubmed/23874234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003641
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