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NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology

Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi-invariant Vα14i-TCR. However, to what extent TCR-mediated signals determine identity and function of mature NKT cells remains incompletely understood. To address this issue, we developed a mouse strain...

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Main Authors: Vahl, J. Christoph, Heger, Klaus, Knies, Nathalie, Hein, Marco Y., Boon, Louis, Yagita, Hideo, Polic, Bojan, Schmidt-Supprian, Marc
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708704/
https://ncbi.nlm.nih.gov/pubmed/23853545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001589
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