Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals

Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secrete...

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Autori principali: Lühr, Inke, Friedl, Andreas, Overath, Thorsten, Tholey, Andreas, Kunze, Thomas, Hilpert, Felix, Sebens, Susanne, Arnold, Norbert, Rösel, Frank, Oberg, Hans-Heinrich, Maass, Nicolai, Mundhenke, Christoph, Jonat, Walter, Bauer, Maret
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708601/
https://ncbi.nlm.nih.gov/pubmed/22776560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.06.014
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